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If you work in clinical diagnostics, environmental or food safety, forensics, or run a mass spec core facility, you know the drill. The goal is to run your analytes smoothly, wrap up on time, and catch the Bruins, Red Sox, or Celtics. But instead:

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You start your day not with a coffee, but with derivatization or another sample prep step.

It’s time-consuming, not everyone can do it, and there’s plenty of room for error that can ruin everything. Still, there’s no way around it if you want to ionize your analyte.

You fire up your HPLC and the pressure is all over the place.

Traditionally, you can’t run LC-MS without an LC, so you start troubleshooting. Bubbles in the mobile phase? Pump seals? Needle seal? One by one. It takes forever, and the sample queue just keeps growing.

You switch from ESI to APCI or APPI.

The more ion sources, the better, right? APCI is great for mid-polar compounds, but once installed, you need to optimize gases, tweak voltage, and make sure everything is reproducible. Sure, there’s an automated setup in the software, but if that fails, you’re stuck in the troubleshooting loop again, with zero samples measured.

Or there’s no molecular peak in your TIC.

Maybe just a few fragments, and that’s it. You start questioning: Is the analyte degraded? Was the sample even correct? Should you dive into deconvolution or start browsing fragment libraries? Either way, it’s everything but straightforward.

And finally, your MS vacuum pump or a PCB gave up yesterday and service won’t arrive for two weeks. Luckily, there’s another instrument from a different vendor.

But now you need to transfer your method. That means new source geometry, new settings, and likely a different ionization response. It should be a piece of cake, but it’s not.

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That’s exactly what this meeting is about.

Jan is a seasoned mass spec expert. During his studies and academic career, he learned firsthand that mass spectrometry is one of the most powerful analytical tools out there. Later, in industry, working with vendor-agnostic solution, he gained deep insights across dozens of applications and vendor ecosystems.

Why talk to Jan?

Because every time Jan talks to labs, one thing stands out: workflows haven’t changed much in the last 20 years. There’s a lot of room to rethink how things are done, and to tackle some of the key challenges head-on.