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Ex­plo­re our re­sour­ces to learn more about the be­ne­fits of SICRIT® and how it can re­vo­lu­tio­ni­ze your work. Get ac­cess to all our app no­tes, pro­duct no­tes, and web­i­nars af­ter en­te­ring your email ad­dress be­low.

App-No­tes
Pro­duct-No­tes
Web­i­nars

App
No­tes

#METABOLOMICS

Trans­la­ting the hu­man body is one the most ex­ci­ting re­se­arch fields our SICRIT® tech­no­lo­gy is be used. Find here all App No­tes on li­pids, breath ana­ly­sis, etc.

List of App No­tes

Me­ta­bo­lo­mic CSI: High Re­so­lu­ti­on Li­pi­do­mic Pro­fil­ing of Fin­ger­prints using TD-SICRIT®-MS and Bio­in­for­ma­tics Pipe­line

We de­mons­tra­te the ca­pa­bi­li­ties of the TD-SICRIT®-MS and how they can be uti­li­zed in the world of me­ta­bo­lo­mics and li­pi­do­mics, with the full po­ten­ti­al of such a stu­dy be­ing rea­li­zed th­rough the com­bi­na­ti­on of che­mis­try and com­pu­ta­ti­on.

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Li­pi­do­mics De­coded: Tar­ge­ted As­sign­ment of Po­lar Li­pids using the SICRIT® LC-Mo­­­­­du­­­­­le

This stu­dy shows that by using the SICRIT® Io­niza­ti­on Tech­no­lo­gy, you can con­duct suc­cessful ana­ly­sis of a wide ran­ge of po­lar li­pids. Ad­di­tio­nal­ly, you can ob­tain a usable MS2 spec­tra that can be used for eit­her tar­ge­ted or un­t­ar­ge­ted ana­ly­sis.

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SICRIT®-HRMS for Me­ta­bo­lic Pro­fil­ing th­rough Di­rect Breath Ana­ly­sis

We de­mons­tra­te an easy ex­ten­si­on of con­ven­tio­nal ca­pa­bi­li­ties for the SICRIT® io­niza­ti­on source, cou­pled to a high-re­­so­lu­­ti­on MS in­stru­ment, th­rough a me­­ta­­bo­­lo­­mic-ba­­sed breath ana­ly­sis and how groups of tar­get mas­ses can be iso­la­ted and ana­ly­zed for po­ten­ti­al bio­mar­ker iden­ti­fi­ca­ti­on.

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LC-SICRIT®-HRMS Ana­ly­sis of Non-Po­lar Li­pids fea­turing Shi­madzu Ne­xera LC and 9030 LC-MS QToF

In this set of me­a­su­re­ments, we de­mons­tra­te the de­tec­tion ca­pa­bi­li­ties of 8 dif­fe­rent Tria­­cyl-gly­ce­ri­­des of va­ry­ing length and sa­tu­ra­ti­on with LC-SICRIT®-HRMS.

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SICRIT®-HRMS for Tar­ge­ted Ex­po­so­mic-Me­ta­bo­lo­mic Re­se­arch th­rough Di­rect Re­spi­ra­to­ry Ana­ly­sis

We de­mons­tra­te an ex­ten­si­on of con­ven­tio­nal ca­pa­bi­li­ties for the SICRIT® Ion Source, cou­pled to a high-re­­so­lu­­ti­on MS in­stru­ment, th­rough a me­­ta­­bo­­lo­­mic-ba­­sed breath ana­ly­sis and how ef­fi­ci­ent it is to con­duct tar­ge­ted stu­dies of dy­na­mic me­ta­bo­lo­mic pro­files, of the lungs, for an in­di­vi­du­al per­son, in real­time.

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SICRIT® – HRMS for Exha­led Breath Ana­ly­sis

We show, how ea­si­ly the SICRIT® Ion Source can be ad­apt­ed to high-re­­so­lu­­ti­on MS in­stru­ments for trace ana­ly­sis of bio­mar­kes and me­ta­boli­tes in exha­led breath.

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#FOOD & ENVIRONMENTAL SAFETY

En­su­ring the safe­ty of the food we con­su­me and the en­vi­ron­ment we live in is a gro­wing prio­ri­ty. SICRIT® tech­no­lo­gy of­fers in­no­va­ti­ve so­lu­ti­ons for de­tec­ting con­ta­mi­nants, pe­sti­ci­des, fla­vor pro­files, and en­vi­ron­men­tal pol­lut­ants with un­pre­ce­den­ted speed and pre­cis­i­on. Ex­plo­re our app no­tes re­la­ted to food safe­ty, en­vi­ron­men­tal con­ta­mi­nants, and aro­ma ana­ly­sis.

List of App No­tes

Qua­li­ta­ti­ve Cross-Over: Using SICRIT® Tech­no­lo­gy to Ana­ly­ze 161 Res­tek GC Pe­sti­ci­des Com­bi­ning the Be­ne­fits of GC and LC

In this stu­dy, we look at 161 uni­que pe­sti­ci­des to de­ter­mi­ne the LC-MS-like io­niza­ti­ons we ge­ne­ra­te and how dif­fe­rent con­di­ti­ons af­fect this soft io­niza­ti­on. Ad­di­tio­nal­ly, we de­ter­mi­ne the ef­fi­ca­cy of using GC-MSMS data ge­ne­ra­ted from a DDA me­thod with an In-House Shi­madzu LC Pe­sti­ci­de Li­bra­ry.

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Quan­ti­ta­ti­ve Snapshot: LOD Ana­ly­sis of 74 LC amen­da­ble Pe­sti­ci­des using the GC-SICRIT® cou­pled to a Shi­madzu 9030 QTOF

This stu­dy aims to de­ter­mi­ne the ge­ne­ra­li­zed LODs and LOQs for se­ve­ral GC pe­sti­ci­de stan­dards using SICRIT® tech­no­lo­gy, as­ses­sing how well the­se li­mits ali­gn with re­gu­la­to­ry re­qui­re­ments.

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Re­a­ding the Tea Lea­ves – Di­rect Head­space Ana­ly­sis of Tea Aro­ma Pro­files by SICRIT® MS

Di­rect sam­ple-pre­pa­ra­ti­on-free ana­ly­sis of tea lea­ves was per­for­med by SICRIT® cou­pled to a com­pact sin­gle quad MS (Wa­ters ACQUITY™ QDa™ De­tec­tor).

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Bet­ter than Jean-Bap­tis­te Gre­nouil­le – Di­rect, Real-Time Head­space Ana­ly­sis of Es­sen­ti­al Oils by SICRIT® MS

In this stu­dy, a di­rect, real-time sample-preparation-free-„sniffing“ ana­ly­sis of es­sen­ti­al oils was per­for­med by SICRIT® cou­pled to a por­ta­ble sin­gle quad MS to clas­si­fy dif­fe­rent ty­pes of es­sen­ti­al oils and to show the sui­ta­b­li­li­ty of this me­tho­do­lo­gy for high th­rough­put ana­ly­sis of es­sen­ti­al oil qua­li­ty and au­then­ti­ca­ti­on ana­ly­sis.

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Swit­ching io­niza­ti­on? No Pro­blem! Ana­ly­sis of 78 pe­sti­ci­des in com­plex ma­tri­ces using a stan­dard LC-ESI work­flow with SICRIT®

In this stu­dy, we uti­li­ze a HRMS cou­pled to the SICRIT® LC-Mo­­­du­­­le to ana­ly­ze 78 pe­sti­ci­des across mul­ti­ple clas­ses when ex­po­sed to se­ve­ral com­plex bio­lo­gi­cal ma­tri­ces to see how well we stand in mi­mi­cking the ESI func­tion­a­li­ty and io­niza­ti­on with an ESI spe­ci­fic me­thod, with ESI do­mi­na­ted ana­lytes of choice.

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Per­for­mance Eva­lua­ti­on of 41 Com­mon Pe­sti­ci­des by LC-SICRIT® fea­turing Shi­madzu LC-40 and 9030 LC-MS QToF

To bridge this gap bet­ween the dif­fe­rent pe­sti­ci­de ana­ly­te clas­ses, and pro­vi­de a new per­spec­ti­ve on LC io­niza­ti­on, we pre­sent SICRIT® LC-Mo­­du­­le. In this stu­dy, we uti­li­ze a HRMS cou­pled to the SICRIT® LC-Mo­­du­­le to ana­ly­ze 41 com­mon pe­sti­ci­des.

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Cha­rac­te­riza­ti­on of cher­ry-type fla­vorings ba­sed on vo­la­ti­le com­pounds by me­ans of the Ha­Voc sen­so­ry sys­tem

Fla­vorings are very po­pu­lar as they pro­vi­de an ex­tra tas­te to foods and be­ver­a­ges such as pa­stries, ice cream, sweets, cof­fee, or tea.

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SICRIT® Tech­no­lo­gy for Fast and Di­rect SPME-MS Ana­ly­sis of En­vi­ron­men­tal Trace Con­ta­mi­nants

We pre­sent a ver­sa­ti­le me­thod for di­rect and quan­ti­ta­ti­ve iden­ti­fi­ca­ti­on of trace con­ta­mi­nants in en­vi­ron­men­tal samples wi­t­hout sam­ple pre­pa­ra­ti­on using SICRIT® Io­niza­ti­on Tech­no­lo­gy.

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Fast and Di­rect De­tec­tion of Per­fluo­ro­car­box­lyic acids (PFCA) with SICRIT®-MS

Per- and po­ly­fluo­ro­al­kyl com­pounds (PFAS), espe­ci­al­ly their car­boxy­lic acids (PFCA), are ubi­qui­tous­ly used che­mi­cals as fla­me re­tar­dants, sur­fac­tants, and coa­tings.

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Soft io­niza­ti­on GC-HRMS of n‑Alkanes C8 – C20 (SCIEX Tri­ple­T­OF® 5600)

We in­tro­du­ce a ver­sa­ti­le new me­thod for trace ana­ly­sis of non-po­lar short-chain n‑alkanes C8-C20 using GC-SICRIT®-HRMS.

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Soft io­niza­ti­on GC-HRMS of n‑Alkanes C8 – C20 (Ther­mo LTQ Or­bi­trap XL)

We in­tro­du­ce a ver­sa­ti­le new me­thod for trace ana­ly­sis of non-po­lar short-chain n‑alkanes C 8 ‑C 20 using GC-SICRIT® ‑HRMS.

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GC soft io­niza­ti­on cou­pling to LC-MS with SICRIT® (Ther­mo LTQ Or­bi­trap XL)

Due to his­to­ric re­asons the world of mass spec­tro­me­try is still di­vi­ded into GC-MS and LC-MS sys­tems and users the­reof.

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Cof­fee Aro­ma Pro­fil­ing – Di­rect SICRIT® HR-MS Ana­ly­sis

Cof­fee is one of the most po­pu­lar be­ver­a­ges and known for its ma­ni­fold aro­ma pro­files.

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#FORENSICS & TOXICOLOGY

In the fields of fo­ren­sics and to­xi­co­lo­gy, fast, ac­cu­ra­te de­tec­tion of ha­zar­dous sub­s­tances can make a life-sa­ving dif­fe­rence. SICRIT® tech­no­lo­gy pro­vi­des cut­ting-edge so­lu­ti­ons for the di­rect ana­ly­sis of che­mi­cal war­fa­re agents, ex­plo­si­ves, and to­xic sub­s­tances, en­ab­ling ra­pid and re­lia­ble re­sults in cri­ti­cal si­tua­tions. Dis­co­ver our app no­tes fo­cu­sed on fo­ren­sic in­ves­ti­ga­ti­ons and to­xi­co­lo­gy ap­pli­ca­ti­ons.

List of App No­tes

Che­mi­cal War­fa­re Agents – Di­rect SICRIT®-MS Ana­ly­sis

Alt­hough che­mi­cal war­fa­re agents (CWA) and their use are out­la­wed, they still are an im­mi­nent th­re­at to peo­p­le all over the world.

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Fast and Di­rect De­tec­tion of Ex­plo­si­ves using SICRIT®-MS

The de­tec­tion of ex­plo­si­ves and ex­­plo­­si­­ve-re­la­­ted com­pounds is a high-prio­­ri­­ty tasks in re­cent ye­ars for home­land se­cu­ri­ty and coun­­ter-ter­ro­rism ap­pli­ca­ti­ons.

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#PHARMA

The phar­maceu­ti­cal in­dus­try de­mands the hig­hest le­vels of sen­si­ti­vi­ty and pre­cis­i­on in drug de­ve­lo­p­ment and qua­li­ty con­trol. SICRIT® tech­no­lo­gy enhan­ces mole­cu­lar ana­ly­sis, en­ab­ling fas­ter de­tec­tion and ac­cu­ra­te pro­fil­ing of cri­ti­cal com­pounds such as ni­tros­ami­nes. Del­ve into our app no­tes show­ca­sing SICRIT® ap­pli­ca­ti­ons in phar­maceu­ti­cal re­se­arch.

List of App No­tes

Com­pa­ri­son of SICRIT® and APCI in the Ana­ly­sis of Ni­tros­ami­nes with Li­quid Chro­ma­to­gra­phy

In this stu­dy we pro­vi­de a di­rect com­pa­ri­son of APCI and the SICRIT® io­niza­ti­on source for the ana­ly­sis of 7 Ni­tros­ami­nes by LC-HRMS.

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GC-SICRIT®-MS: Fast and sen­si­ti­ve ana­ly­sis of 6 ni­tros­ami­nes by re­pla­cing he­li­um with hy­dro­gen as car­ri­er gas

A fast de­ter­mi­na­ti­on of 6 ni­tros­ami­ne com­pounds by GC-SICRIT®-(LC)MS is de­mons­tra­ted.

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Ul­tra-Sen­si­ti­ve GC-SICRIT®-HRMS Ana­ly­sis of Ni­tros­ami­nes in Phar­maceu­ti­cal Samples fea­turing Hy­dro­gen as GC Car­ri­er Gas and Shi­madzu LCMS-9030 QToF

In this stu­dy we de­mons­tra­te ul­­tra-sen­­si­­ti­­ve de­ter­mi­na­ti­on of va­rious ni­tros­ami­ne com­pounds by GC-SICRIT®-MS using H2 as car­ri­er gas and full scan high re­so­lu­ti­on MS data from Shi­madzu LCMS-9030.

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Ul­tra-Sen­si­ti­ve GC-SICRIT®-HRMS Ana­ly­sis of Ni­tros­ami­nes in Phar­maceu­ti­cal Samples fea­turing Hy­dro­gen as GC Car­ri­er Gas and Shi­madzu LCMS-9030 QToF

Ni­tros­ami­ne have emer­ged as im­pu­ri­ties of ma­tu­re con­cern in phar­maceu­ti­cal pre­pa­ra­ti­ons. In­iti­al­ly de­tec­ted by the US FDA in drugs used in the tre­at­ment of hy­per­ten­si­on and he­art fail­ure con­tai­ning Sar­tan as ac­ti­ve phar­maceu­ti­cal in­gre­di­ents.

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Sen­si­ti­ve De­tec­tion of Ni­tros­ami­nes for Drug Qua­li­ty Con­trol using SICRIT® Soft Io­niza­ti­on-MS

In this stu­dy we de­mons­tra­te sen­si­ti­ve de­ter­mi­na­ti­on of ni­tros­ami­ne com­pounds by GC-soft io­­ni­za­­ti­on-MS out­per­forming GC-MS and LC-MS me­thods in view of drug qua­li­ty con­trol.

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#IMAGING

Mole­cu­lar ima­ging plays a pi­vo­tal role in ad­van­cing sci­en­ti­fic re­se­arch. SICRIT® of­fers in­no­va­ti­ve ima­ging tech­ni­ques that com­bi­ne la­ser ab­la­ti­on with mass spec­tro­me­try, pro­vi­ding high-re­so­lu­ti­on in­sights into mole­cu­lar struc­tures. Ex­plo­re our app no­tes on mole­cu­lar ima­ging.

List of App No­tes

Mole­cu­lar ima­ging using la­ser ab­la­ti­on-pos­tio­niza­ti­on mass spec­tro­me­try

Here, a com­ple­te so­lu­ti­on is pre­sen­ted for con­ver­ting any mass spec­tro­me­ter (MS) with an at­mo­sphe­ric pres­su­re in­let (LC-MS) into a la­ser ab­la­ti­on (LA)-MS for ima­ging using the SICRIT® Ion Source.

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Pro­duct
No­tes

#Ion Source #SC-30

SICRIT® Io­niza­ti­on Set SC-30

The SICRIT® (Soft Io­niza­ti­on by Che­mi­cal Re­ac­tion In Trans­fer) SC-30 Io­niza­ti­on Set is a plug & play flow­th­rough io­niza­ti­on add-on for mass spec­tro­me­ters with an at­mo­sphe­ric pres­su­re in­let. It can be in­ter­faced with al­most all LC-MS sys­tems on the mar­ket.

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Photograph of Plasmion's GC/SPME Mo­du­le resembling the topic of the offered product note on Plasmion Downloads

#GC-SPME

SICRIT® GC/SPME Mo­du­le

The SICRIT® GC/SPME Mo­du­le con­nects sta­te-of-the-art sam­ple en­rich­ment and se­pa­ra­ti­on tech­ni­ques with your SICRIT® Ion Source.

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Photograph of Plasmion's Hea­ted Trans­fer Line resembling the topic of the offered product note on Plasmion Downloads

#Sam­pling-Line

SICRIT® Hea­ted Sam­pling Line

The SICRIT® Hea­ted Sam­pling Line is de­si­gned to im­pro­ve the coll­ec­tion and trans­port of ana­lytes to the MS and al­lows for count­less new ways to bring samples to the MS in­stru­ment.

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Photograph of Plasmion's LC/SFC Mo­du­le resembling the topic of the offered product note on Plasmion Downloads

#LC-SFC-Mo­du­le

SICRIT® LC/SFC Mo­du­le

The SICRIT® LC/SFC Mo­du­le en­ables the con­nec­tion from con­ven­tio­nal li­quid or su­per­cri­ti­cal flu­id chro­ma­to­gra­phy to mass spec­tro­me­ters using the SICRIT® Ion Source.

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Web­i­nars

21.11.2024

Web­i­nar: Ex­plo­ring Me­ta­bo­lo­mics with SICRIT®

Dr. Jan Bucek

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07.03.2024 SICRIT® UNIVERSE Event 2024

Ra­pid un­t­ar­ge­ted puff-by-puff ana­ly­sis of (elec­tro­nic) ci­ga­ret­te ae­ro­sols by SICRIT®-MS

Yong-Qi (Alex) Gao

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20.06.2024

Web­i­nar: Ana­ly­zing Pe­sti­ci­des with SICRIT®

Dr. Jan Bucek

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07.03.2024 SICRIT® UNIVERSE Event 2024

Our ex­pe­ri­en­ces de­ve­lo­ping SICRIT® me­thods for di­rect ana­ly­sis

Prof. Dr. Ni­co­le Stritt­mat­ter (TU Mu­nich)

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07.03.2024 SICRIT® UNIVERSE Event 2024

De­ve­lo­p­ment of a very fast me­thod for au­then­ti­ca­ti­on ana­ly­sis of food ex­ploi­ting mole­cu­lar fin­ger­prints using a di­rect in­jec­tion ap­proach via SICRIT®-q-TOF-MS and sub­se­quent mul­ti­va­ria­te data ana­ly­sis

Dr. An­dre­as Schmid­ber­ger (La­bor Fried­le)

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07.03.2024 SICRIT® UNIVERSE Event 2024

SICRIT® for Enhan­ced Qua­li­ty Con­trol of Phy­to­phar­maceu­ti­cals and Es­sen­ti­al Oils: Me­thod De­ve­lo­p­ment and Ap­pli­ca­ti­ons

Dr. Chris­ti­an Steu­er (ETH Zü­rich)

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07.03.2024 SICRIT® UNIVERSE Event 2024

In­ter­fa­cing LC-ESI and GC-DBDI to the same in­stru­ment a ver­sa­ti­le set­up for a MS Core Fa­ci­li­ty

Dr. Na­ta­lia Gasi­l­o­va (EPFL Lau­sanne)

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19.02.2024

Ra­pid ana­ly­sis of il­li­cit drugs and che­mi­cal pro­fil­ing of fin­ger­prints

Dr. Jan Bucek (Plas­mi­on)

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Cover slide of the webinar about Webinar03 SICRIT MS For In Situ implying its streaming offer on Plasmion Downloads

23.11.2021

SICRIT®-MS for in-situ ana­ly­sis of VOCs in va­rious samples -

Prof. Zhou Jiang (Pe­king Uni­ver­si­ty)

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Cover slide of the webinar about Webinar04 HELIOS SICRIT Mass Spectrometry implying its streaming offer on Plasmion Downloads

23.11.2021

HELIOS/SICRIT®/mass spec­tro­me­try for ana­ly­sis of ae­ro­sols in en­gi­ne ex­haust -

Prof. Chris­toph Ha­isch ( TU Mu­nich)

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Cover slide of the webinar about Beyond Standard Analytical Workflows implying its streaming offer on Plasmion Downloads

23.11.2021

Bey­ond stan­dard ana­ly­ti­cal work­flows – Cou­pling of GC and Shi­madzu LCMS in­stru­ments with Plas­mi­on SICRIT® Ion Source -

Dr. Sa­scha Rex­roth (Shi­madzu)

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Cover slide of the webinar about Experiences With The Plasmion SICRIT implying its streaming offer on Plasmion Downloads

23.11.2021

Ex­pe­ri­en­ces with the Plas­mi­on SICRIT® Flow-th­rough Dielec­tric Bar­ri­er Di­schar­ge Ion Source -

Ro­bert (Chip) Cody, Ph.D. (JEOL)

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Cover slide of the webinar about Real Time Monitoring Of Cereal Roasting implying its streaming offer on Plasmion Downloads

23.11.2021

Real-time mo­ni­to­ring of ce­re­al roas­ting pro­ces­ses by ul­tra-hi­gh­res­o­lu­ti­on mass spec­tro­me­try with plas­mi­on io­niza­ti­on -

Leo­pold Weid­ner (HHZ Mu­nich)

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Cover slide of the webinar about Webinar02 GC Coupling implying its streaming offer on Plasmion Downloads

05.05.2020

GC Cou­pling to LC-MS In­stru­ments ‑Ex­pand your Mass Spec­tro­me­tric “View” with SICRIT® -

Dr. Jan-Chris­toph Wolf (Plas­mi­on)

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Cover slide of the webinar aboutWebinar01 Direct MS Screening implying its streaming offer on Plasmion Downloads

04.05.2020

Di­rect MS Scree­ning – Get Re­sults Fas­ter with SICRIT® -

Dr. Jan-Chris­toph Wolf (Plas­mi­on)

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