MS
Imaging
The SICRIT® Ion Source in combination with a laser ablation setup or as post-ionization device for (AP-) MALDI enables MS imaging down to 5μm.
High Resolution Laser Ablation
The combination of a UV-laser ablation system with the flow-through SICRIT® Ion Source allows for a efficient, soft ionization-based visualization of molecules with a very high spatial resolution.
The SICRIT® ion source can be hyphenated to any commercial laser ablation system and nearly any API mass spectrometer that is commercially available. This makes this technique easy to adapt to individual needs regarding the sample type and analytical question.“
Elia, E.A. et al, Anal. Chem. 2020, 92, 15285–15290
Postionization For (AP)Maldi
Using the flow-through SICRIT® Ion Source as post-ionization device for AP-MALDI imaging allows to ionize and visualize additional molecules that have not been ionized with the primary ionization source. This significantly expands the mass spectrometric view on the sample in an MS imaging approach.
The ease with which the SICRIT® device can be installed and the minimal need for optimization presents this commercially available tool as an attractive method for simple post-ionization for any AP-MALDI MS imaging.“
Elia, E.A. et al, Anal. Chem. 2020, 92, 15285–15290
Related Papers
Atmospheric-Pressure Infrared Laser-Ablation Plasma-Postionization Mass Spectrometry Imaging
Here, we present a novel modality, atmospheric-pressure infrared laser-ablation plasma postionization (AP-IR-LA-PPI), with the first proof-of-concept examples of MSI for FFPE and fresh-frozen tissues, with no post-sectioning sample preparation.
Mass Spectrometry Imaging Using MALDI Coupled with Plasma-Based Post-Ionization
Here we report the development and optimization of a mass spectrometry imaging (MSI) platform that combines an atmospheric-pressure matrix-assisted laser desorption/ionization platform with plasma postionization (AP-MALDI-PPI) and trapped ion mobility spectrometry (TIMS).
Discover our Products
Find the perfect solution for your use case, with Plasmion’s advanced technology and expertise in chemical analysis for research or industry.