Direct MS-Based Breath
Analysis
The SICRIT ® Solution for Breath Analysis: Biomarker discovery in exhaled breath enabling non invasive clinical diagnostics based on direct MS.
Breath
Exemplary
Results
Enabling biomarker discovery & metabolism monitoring
With the SICRIT® Breath Analysis Module we are able to provide non-invasive sample collection techniques, such as breath analysis. Combining this technology with the SICRIT® ionization source we are able to conduct metabolic monitoring of the volatile compounds that are present in a person’s breath. Here, we can do both real-time analysis of a person’s metabolism and identify potential biomarkers.
As seen from the image, with our minimal fragmentation and clean MS1 spectra, we can easily produce these full spectrum views of both targeted and non-targeted biomarkers, allowing for more efficient processing and observation of complex samples, such as breath.
With the SICRIT® Breath Analysis Module coupled to the SICRIT® ionization source, we are able to ionize a wide array of polar and non-polar compounds with an increased level of sensitivity, of a person’s breath. This allows for a unique profile to be collected from each individual, creating a unique metabolomic fingerprint. In this particular study, we are able to show how two individuals will differ in their metabolomic profiles. Furthermore, the same experiment is applied to the same individual and the changes within the profile that occur over time.
Since the SICRIT® ionization source, and subsequently the SICRIT® Breath Analysis Module, can be coupled to any mass spectrometer, you can also conduct breath analysis with your instrument of choice, whether it be with High Resolution or Low Resolution.
Here, you can see from a targeted analysis approach using the SICRIT® Breath Analysis Module that with the High Resolution you can easily interpret the direct measurement results at the MS1 spectra level.
Related App Notes
SICRIT®-HRMS for Targeted Exposomic-Metabolomic Research through Direct Respiratory Analysis
We demonstrate an extension of conventional capabilities for the SICRIT® ionization source, coupled to a high-resolution MS instrument, through a metabolomic-based breath analysis and how efficient it is to conduct targeted studies of dynamic metabolomic profiles, of the lungs, for an individual person, in realtime.
SICRIT® – HRMS for Exhaled Breath Analysis
We show, how easily the SICRIT® Ion source can be adapted to high-resolution MS instruments for trace analysis of biomarkes and metabolites in exhaled breath.
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